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products:
Serum Institute of India-
Diphtheria & Tetanus Vaccine
Name: Diphtheria and
Tetanus Vaccine, Adsorbed for adults and adolescents
Precautions: ADRENALINE INJECTION
(1:1000) MUST BE IMMEDIATELY AVAILABLE SHOULD AN ACUTE ANAPHYLACTIC
REACTION OCCURS DUE TO ANY COMPONENT OF THE VACCINE. For treatment of
severe anaphylaxis the initial dose of adrenaline is 0.1-0.5 mg
(0.1-0.5ml of 1:1000 injection) given s/c or i/m. Single dose should not
exceed 1 mg (1ml). For infants and children the recommended dose of
adrenaline is 0.01mg/kg (0.01ml/kg of 1:1000 injection). Single
paediatric dose should not exceed 0.5mg (0.5ml). The mainstay in the
treatment of severe anaphylaxis is the prompt use of adrenaline, which
can be lifesaving. It should not be used at the first suspicion of
anaphylaxis.
As with the use of all vaccines the vaccinees should remain under
observation for not less than 30 minutes for the possibility of
occurrence of immediate or early allergic reactions. Efcorlin
hydrochloride and antihistaminics should be available in addtion to
supportive measures such as oxygen inhalation.
There is an increased incidence of local and systemic reactions to
booster doses of tetanus toxoid when given to previously immunized
persons. Special care should be taken to ensure that the injection does
not enter a blood vessel.
IT IS EXTREMELY IMPORTANT WHEN THE PARENT, GUARDIAN, OR ADULT PATIENT
RETURNS FOR THE NEXT DOSE IN THE SERIES, THE PARENT, GUARDIAN,OR ADULT
PATIENT SHOULD BE QUESTIONED CONCERNING OCCURRENCE OF ANY SYMPTOMS
AND/OR SIGNS OF AN ADVERSE REACTION AFTER THE PREVIOUS DOSE.
Drug Interactions: If DTP and TIG or
Diphtheria Antitoxin are administered concurrently, seperate syringes
and separate sites should be used.
As with other intramuscular injections, use with caution in patients on
anticoagulant therapy.
Immunosuppressive therapies, including irradiation, antimetabolites,
alkylating agents, cytotoxic drugs and corticosteroids used in greater
than physiologic dose may reduce the immune response to vaccines.
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